Preclinical Imaging Research

The Ohio Clinical Trials Collaborative offers Preclinical Imaging Research in animals to test the efficacy and biodistribution of drugs at Case Western Reserve University. The Case Center for Imaging Research (CCIR) was established in 2004 to provide a comprehensive suite of preclinical and clinical imaging instrumentation and expertise including in vivo Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), X-ray Computed Tomography (CT), as well as multiple optical imaging capabilities including conventional bioluminescence and fluorescence.

The CCIR also houses a novel cryoimaging system that provides whole-animal, 3D brightfield and fluorescence images at 1-10 micron resolution. The CCIR has on-site animal housing and surgical suites supporting longitudinal imaging studies as well as a state-of-the-art radiochemistry laboratory to synthesize and evaluate radionuclide-labeled drug candidates. Importantly, the CCIR was established as a shared resource to provide imaging services and expertise to all regional academic and industrial partners.

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Preclinical Imaging Capabilities

  • Radiochemistry Synthesis
  • Magnetic Resonance Imaging
  • Positron Emission Tomography (PET)
  • Scintigraphy
  • X-ray / Computed Tomography (CT)
  • Bioluminescence
  • Fluorescence
  • In Situ CryoImaging
  • Image Processing / Quantification

Visit the Imaging Facility’s site: http://ccir.case.edu/

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The CCIR provides a one-stop shopping opportunity to perform a wide range of imaging experiments and to quantitatively assess therapeutic efficacy, drug distribution and disease progression.

These capabilities are tailored to address our client’s specific needs through imaging research faculty with decades of experience using MRI, x-ray, CT, PET, bioluminescence, fluorescence and novel cryo-fluorescence equipment.

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Applications and Expertise

  • Drug Biodistribution
  • Anatomic Imaging / Visualization
  • Gene Expression Imaging
  • Cancer imaging
  • Cardiovascular imaging
  • Metabolism
  • Lipid Biodsitribution
  • Targeted Imaging / Drug Delivery
  • Nanotechnology Development
  • Imaging Physics and Engineering
  • Pharmacokinetic Modelling

These imaging services provide a mechanism to noninvasively and longitudinally assess disease progression, therapeutic efficacy, and pharmacodynamics including whole body drug distribution studies.

Sponsors can access a full range of Preclinical Imaging Research services through the OCTC including radionuclide labelled drug synthesis, MRI, advanced x-ray, and molecular and whole body imaging technologies for drug development.  In addition, the CCIR offers support for image processing and quantitative image analysis including tissue perfusion, diffusion, morphometric, image co-registration, and segmentation.

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Chris Flask, PhD
Associate Professor of Radiology
Scientific Director – Case Center for Imaging Research

Dr. Chris Flask, Scientific Director of the CCIR, is an experienced MRI physicist with over 15 years of preclinical and clinical imaging research experience. In addition, the CCIR and CWRU have over 20 imaging research faculty with diverse expertise who support a wide variety of Preclinical and Clinical Imaging Research studies.

Contact Information: 216.844.4963 caf@case.edu